Largest Multi-Surgeon Prospective Study Supports Wider Adoption of Modern Medially Stabilised Knee Design
New clinical evidence has demonstrated excellent patient outcomes, high satisfaction rates and low revision rates following implantation of the Saiph® Medially Stabilised (MS) Knee System, supporting the growing body of evidence behind the medially stabilised philosophy in total knee arthroplasty (TKA).
Published from a prospective, multi-centre cohort study involving 15 surgeons across 16 hospitals, the research evaluated outcomes in 608 primary total knee arthroplasties performed using a second-generation medially stabilised knee design. The study represents the largest prospective, multi-surgeon investigation reported to date examining the introduction of a new-generation MS knee platform in routine clinical practice.
Strong Results Across a Broad Primary Knee Population
A total of 548 knees were available for final review at two years, achieving an impressive 90.8% follow-up rate. The patient cohort reflected a typical primary TKA population, providing valuable insight into the real-world performance of the implant across a wide range of patients and surgeons.
Clinical outcomes demonstrated significant improvements across every reported metric from pre-operative baseline to 24 months post-operatively, including:
These findings indicate that the medially stabilised design can deliver both excellent functional performance and durability in the early post-operative period.
Exceptional Patient Satisfaction
Perhaps most notable were the levels of patient satisfaction reported at two years following surgery.
High satisfaction remains one of the most important measures of success following total knee replacement. These results suggest that the medially stabilised knee concept may help address some of the unmet expectations often associated with conventional knee replacement designs.
Supporting the Medially Stabilised Philosophy
The medially stabilised approach seeks to better replicate the natural kinematics of the native knee by providing a highly congruent medial compartment while allowing controlled motion laterally. This philosophy has gained increasing attention from surgeons worldwide as they seek to improve functional outcomes and patient perception following TKA.
While previous studies have reported encouraging findings, evidence has often been limited by small patient numbers, single-surgeon experiences or short follow-up periods. This study provides robust prospective data collected across multiple surgeons and centres, helping demonstrate that excellent outcomes can be consistently achieved in routine clinical practice.
What This Means for Surgeons
The results indicate that a second-generation medially stabilised knee design can be successfully adopted across diverse surgical practices while maintaining:
The authors conclude that the findings support the wider adoption of modern medially stabilised knee technology and provide further evidence that the design philosophy can deliver outcomes exceeding those typically reported for traditional total knee arthroplasty designs.
About Saiph®
The Saiph® Knee System was developed around the principles of medial stability and natural knee motion. Through its anatomically inspired design and focus on restoring functional kinematics, Saiph aims to help surgeons deliver a stable, confident and satisfying knee replacement experience for their patients.
As evidence supporting medially stabilised knee arthroplasty continues to grow, studies such as this reinforce the value of designs that prioritise both objective clinical outcomes and the patient's perception of their new knee.
Ref: Improved Pain and Function, Low Complication Rates, and 95% Patient Satisfaction at 2 Years After Medially Stabilized Total Knee Arthroplasty: A Prospective Multicenter Cohort Study. J. Baré et al
Read the paper: https://doi.org/10.1016/j.artd.2026.102051